Terwijl overheid en zorgverzekeraars proberen de omvang van de traditionele tweedelijns ggz voor common mental disorders en van de langdurige zorg voor patiënten met ernstige psychiatrische aandoeningen (epa’s) terug te brengen door ingrepen in de bekostiging van de zorg, breekt er in de wetenschappelijke psychiatrie een ontwikkeling door die op langere termijn veel betere perspectieven biedt op gezondheidswinst tegen lagere kosten.
Geneticists at the University of Pittsburgh Graduate School of Public Health will provide their scientific expertise to a new initiative aimed at preventing and reducing the adverse effects of medications in people with mental illnesses.
The research project will take a personalized medicine approach to managing drug therapy by analyzing each patient’s genetic makeup to determine potential adverse reactions to medications. Funded by the Polk Foundation, it will be led by NHS Human Services, one of the nation’s largest providers of human services, in collaboration with Pitt Public Health; CareKinesis Inc., a medication therapy management services provider; and Coriell Life Sciences, a pharmacogenomics testing vendor.
“An individual’s genetic makeup defines how many common drugs are processed by the body and who is at risk for an adverse drug response from such therapies,” said Dietrich Stephan, Ph.D., professor and chair of the Department of Human Genetics at Pitt Public Health. “Individuals can suffer immensely from the very drugs that are meant to improve their health if given drugs they cannot tolerate, often resulting in increased emergency room visits and elevated health care costs.”
For example, some people are genetically predisposed to metabolize certain drugs faster than the average person, causing them to have a stronger, more immediate response to medication. When someone is prescribed multiple medications, such responses can cause unexpected and potentially dangerous drug interactions.
“The people at highest risk, such as the aged and mentally ill, often are prescribed a multitude of drugs with no insight into their genetic susceptibilities,” said Dr. Stephan, who also serves as associate director of the Institute for Personalized Medicine, a collaboration between Pitt and UPMC. “In this study, we aim to systematically implement comprehensive genetic testing in these populations and develop the evidence around improved outcomes and reduced costs that allows such testing to be broadly […]